19th European Meeting on Complement in Human Diseases: Program

The first day of the scientific program will comprise a Teaching Day designed to provide first insights into the composition and basic functions of the complement system to those new to the field. The Teaching Day is paralleled by a Satellite Symposium, at which distinguished lecturers from industry, basic science as well as clinicians will discuss the role of C3, C5 and their cleavage products as targets in inflammatory diseases. The Satellite Symposium is in line with the core EMCHD 2024 program focusing on recent developments in the complement field to translate basic scientific advancements into novel therapeutic approaches to combat human diseases.

Link to Submission Guidelines

Conference Schedule Sep 2 - 6, 2024

07:30 - 16:00

07:30 - 16:00
Conference Registration

08:45 - 17:15

08:45 - 17:15	AM 1
Satellite Symposium Details can be found on a separate page.

AM 1

08:45 - 16:30

08:45 - 16:30	AM 3
Teaching Day Details can be found on a separate page.

AM 2

16:45 - 17:45

16:45 - 17:45	AM S2
ECCO Meeting

AM S2

19:00 - 20:15

19:00 - 20:15
Welcome Reception in St. Petri

19:00 - 20:15

19:00 - 20:15
Welcome Reception in St. Petri Part 1

20:15 - 20:30

20:15 - 20:30
Official Welcome by Conference Chair and ECN President

20:30 - 21:00

20:30 - 21:00
Science Slam

21:00 - 22:30

21:00 - 22:30
Welcome Reception in St. Petri Part 2

07:30 - 17:30

07:30 - 17:30
Conference Registration

08:30 - 09:00

08:30 - 09:00
Opening / Welcome Address

09:00 - 10:00

09:00 - 10:00	AM 1
Key Note Lecture Introduced by Jörg Köhl Mihalis Lionakis, National Institutes of Health (NIH) Bethesda, USA Innate immunity against fungi and the role of complement

AM 1

10:00 - 10:30

10:00 - 10:30
Coffee Break

10:30 - 11:30

10:30 - 11:30	AM 1
Session 1 Complement in infection
Chairs: Mikkel-Ole Skjødt, Reinhard Würzner

AM 1

The Association Between CFHR-3/CFHR-1 Gene Deletions and the Severity of Malaria Infection

Alliyah Byrd, Lucy Wahler, Timo Reiss, Andres Gonzalez-Delgado, Anna Bachmann, Rolf Fendel, Christine Skerka, Gabriele Pradel

A complement-based therapeutic approach against fungal infections with promising results in a murine model of invasive pulmonary aspergillosis

Verena Harpf, Cornelia Speth, Günter Rambach, Verena Fleischer, Reinhard Würzner, Peter Garred, Anne Rosbjerg

Post-acute COVID-19 Syndrome (PACS) and Its link to C1 Esterase Inhibition

Isaac Melamed

Two novel cases of Factor D deficiency

Mathilde Puel, Kenza Rwayane, Paula Vieira Martins, Marwa Chbihi, Eric Jeziorski, Frédéric Rieux-Laucat, Jéremie Rosain, Véronique Frémeaux Bacchi, Carine El Sissy

11:30 - 12:30

11:30 - 12:30	AM 1
Session 2 Complement targeting in the clinic
Chairs: Michael Holers, Claire Harris

AM 1

Application of anti-C4d antibody as a novel and universal strategy to overcome the resistance of cancer cells to first-line immunotherapy

Daria Kowalska, Marcin Okrój

Complement regulator CD55 deficient protein-losing enteropathy (CHAPLE disease): successful treatment with pozelimab in two sisters

Nikki van der Kruk, Esther CW de Boer, Richard B Pouw, Taco W Kuijpers, Johan E van Limbergen

Bi-specific antibodies targeting endogenous complement inhibitors for targeted local complement inhibition in the context of rheumatoid arthritis

Haiyu Wang, Paul Parren, Leendert Trouw

Convertase-Typing assisted by Artificial Intelligence Shows Contribution of Different Complement Convertases in Glomerular Diseases

Tilman Schmidt, Mercedes Noriega, Sergey Biniaminov, Timo Koch, Philipp Marquardt, Sonia Wulf, Elion Hoxha, Nicola Martin Tomas, Tobias B Huber, Christine Skerka, Peter F Zipfel, Thorsten Wiech

12:30 - 12:45

12:30 - 12:45
Group Photo

12:45 - 13:30

12:45 - 13:30	AM 1
Lunch Seminar InflaRx InflaRx – complement C5a/C5aR inhibition in human disease with best-in-class inhibitors

AM 1

12:45 - 14:15

12:45 - 14:15	Foyer
Lunch

Foyer

12:45 - 14:15

12:45 - 14:15	AM S2
ECN Board Meeting

AM S2

14:15 - 16:15

14:15 - 16:15	AM S1, 3, 4
Poster session 1 (with coffee and snacks)

AM S1, 3, 4

16:15 - 17:30

16:15 - 17:30	AM 1
Session 3 Complement diagnostic and biomarkers
Chairs: Christoph Schmidt, Nicole Schäfer

AM 1

Clinical and histological significance of complement terminal pathway activation and intra renal immune response in C3 glomerulopathy

Marie-Sophie Meuleman-Feger, Matthew C Pickering, Mikel Rezola Artero, Lubka T Roumenina, Véronique Frémeaux- Bacchi, Jean-Paul Duong Van Huyen, Sophie Chauvet

O10

HDL-associated CFH and modified HDL levels are indicators of stable plaques in lower extremity arterial disease patients

Eija Nissilä, Shahan Syed, Pavel Uvarov, Inkeri Lokki, Larisa Chernyaeva, Essi Roininen, Emilia Vataja, Antti Tuhkala, Salla Keskitalo, Christina Mendoza, Seppo Meri, Minna Holopainen, Reijo Käkelä, Markku Varjosalo, Juha Sinisalo, Karita Haapasalo

O11

Complement in blood and urine as biomarkers to evaluate in IgA Nephropathy and IgA Vasculitis with renal involvement

Mazdak Sanaei Nurmi, Laura Pérez-Alós, Bengt Fellström, Peter Garred, Sigrid Lundberg

O12

Autoantibodies targeting the complement protease C1s in systemic lupus erythematosus patients with active nephritis, arthritic flare and neuropsychiatric SLE

Jeanne Vigne, Nolwenn Haut, Giovanna Clavarino, Françoise Sarrot-Reynauld, Noémie Jourde-Chiche, Leendert A Trouw, Federica Defendi, Nicole M Thielens, Christine Gaboriaud, Véronique Rossi, Chantal Dumestre-Pérard

O13

Plasma glycated CD59, a Novel Biomarker for Gestational Diabetes

Michelle Toth Castillo, Shauntina Powell, Amy Biermann, Jose Halperin

17:30

17:30
End of Scientific Program Day 2

17:30 - 19:00

17:30 - 19:00	Foyer
Networking Event Hycult 30th anniversary

Foyer

19:00 - 22:00

19:00 - 22:00
LOC Dinner (by invitation only)

07:45 - 14:00

07:45 - 14:00
Conference Registration

08:30 - 09:30

08:30 - 09:30	AM 1
Key Note Lecture Introduced by Markus Huber-Lang Christine Klein, University of Lübeck Lübeck, Germany Parkinson’s disease: At the crossroads of genetics, environmental factors, and the complement system

AM 1

09:30 - 10:45

09:30 - 10:45	AM 1
Session 4 Complement activation and regulation
Chairs: Peter Zipfel, Wenchao Song

AM 1

O14

Revealing complement regulatory functions of Thrombospondin-1 as new potential mechanism in renal disease

Swagata Konwar, Todor Tschongov, Sophie Schroda, Jessika Kleindienst, Eva L. Decker, Martin Pohl, Barbara Zieger, Jens Panse, Hong Wang, Robert Grosse, Manuel Rogg, Christoph Schell, Sabine Vidal, Xiaobo Liu, Christian Gorzelanny, Karsten Häffner

O15

The Schizophrenia-associated protein CSMD1 is a classical pathway inhibitor predominantly expressed by astrocytes and at synapses in mouse and man

Robert Byrne, Jacqui Nimmo, Megan Torvell, Sarah Carpanini, Nikoleta Daskoulidou, Timothy Hughes, Lewis Watkins, Aurora Veteleanu, Wioleta Zelek, Michael O'Donovan, Paul Morgan

O16

Complement factor H-related protein 1 participates in kidney impairment in IgA Nephropathy via canonical and non-canonical function

Yuqi Kang, Xiaohan Yuan, Xianzhi Li, Sufang Shi, Jicheng Lv, Hong Zhang, Li Zhu

O17

Tracking the cell origin of the classical complement pathway C1 proteases in renal tumors and normal tissues

Christine Gaboriaud, Nicolas S Merle, Nolwenn Haut, Artemis Angelidou, Julie Peliconi, Idris Boudhabhay, Alessandra Zarantonello, Mikel Resola Artero, Nicole M Thielens, Véronique Rossi, Lubka Roumenina

O18

Granzyme K activates a new complement pathway

Carlos Donado, Erin Theisen, A. Helena Jonsson, Michael Brenner

10:45 - 11:15

10:45 - 11:15
Coffee Break

11:15 - 12:00

11:15 - 12:00	AM 1
Session 5 Complement crosstalk
Chairs: Mihàly Józsi, Yves Laumonnier

AM 1

O19

Complement activation on shear stress mediated neutrophil lipid nanotubes

Xiaobo Liu, Alexander Thomas Bauer, Rebecca Halbgebauer, Markus Huber-Lang, Christian Gorzelanny

O20

Differences in glycocalyx composition as well as protection from complement and coagulation in genetically modified porcine endothelial cells

Mitra Gultom, Nina Thomi, Svenja Büttiker, Cedric Zimmermann, Angelika Schnieke, Konrad Fischer, Elisabeth Kemter, Eckhard Wolf, Falk Buettner, Robert Rieben

O21

Factor H is a novel ligand for inducible T-cell co-stimulator (ICOS) promoting survival of regulatory T-cells in the glioma microenvironment

Karolina I. Smolag, Jakub Olszowka, Rebecca Rosberg, Elinn Johansson, Elisabet Marinko, Karin Leandersson, David O´Connell, Valeria Governa, Emre Can Tüysüz, Mattias Belting, Alexander Pietras, Myriam Martin, Anna M. Blom

12:00 - 13:00

12:00 - 13:00	AM 1
Session 6 Function and targeting of the anaphylatoxins and their receptors
Chairs: Christian Karsten, Christina Lamers

AM 1

O22

Intranasal C3a treatment attenuates secondary neurodegeneration after ischemic stroke

Marcela Pekna, Anna Stokowska, Markus Aswendt, Stephanie Lohmann, Ruslan Klassen, Frederique Wieters, Yixian Li, Pavel Abaffy, Mikael Kubista, Lukas Valihrach, Mathias Hoehn, Milos Pekny

O23

Genetic ablation of C3aR signaling slows down ALS progression via modulation of astrocyte reactivity

Milos Pekny, Yixian Li, Ulrika Wilhelmsson, Pavel Abaffy, Paulina Penningh, Sarka Benesova, Yolanda de Pablo, Thomas Olsson Bontell, Mikael Kubista, Lukas Valihrach, Marcela Pekna

O24

Colon-targeted complement C5aR1 inhibition using pH-sensitive nanoparticles ameliorates experimental colitis

Cedric Cui, John Lee, Trent Woodruff

O25

A potential role for the C5/C5aR1 axis in the dynamics of the germinal center reaction

Philip Eisenberg, Sina Borus, Samyr Kenno, Jörg Köhl

13:00 - 14:00

13:00 - 14:00
Lunch

13:00 - 14:00

13:00 - 14:00	AM S2
ICW Board Meeting

AM S2

14:00 - 15:00

14:00 - 15:00	AM 1
Session 7 Preclinical models of complement-related diseases
Chairs: Leendert Trouw, Kevin Marchbank

AM 1

O26

Collectin-10 plays a pivotal role in the development of hepatic ischemia/reperfusion injury in mice

Tatsuro Sugaya, Takeshi Machida, Yumi Ishida, Daiki Yoshida, Manabu Hayashi, Masayuki Sekimata, Hiromasa Ohira, Hideharu Sekine

O27

Complement inhibition in brain using a brain-penetrant MAC-blocking monoclonal antibody reduces pathology and cognitive decline in an Alzheimer model

Wioleta M Zelek, Ryan J Bevan, Jacqui Nimmo, Maarten Dewilde, Bart De Strooper, B. Paul Morgan

O28

In from the cold – HDM-FH protects human kidneys in a simulated organ transplant model

Beth G. Gibson, Chloe Connelly, Harriet Denton, Samuel J. Tingle, Madison Cooper, Georgios Kourounis, Saimir Luli, Lucy Bates, Marnie Brown, Balaji Mahendran, Emily Thompson, Colin H. Wilson, Neil S. Sheerin, Kevin J. Marchbank

O29

Protecting Biomedical Surfaces against Complement: Employing Glycoengineered Bacterial and Endothelial Cell Assays to Investigate Regulator-Recruiting Surface Coatings

Jannes Felsch, Aleksandra Blagojevic, Gabriel Sommerfeld, Simona Jacquemai, Ekaterina Umnyakova, Daniel Ricklin

15:00

15:00
End of Scientific Program Day 3

16:00 - 18:00

16:00 - 18:00
Social Excursions Boat trip, City walk or European Hansemuseum

19:00 - 22:00

19:00 - 22:00
Pubquiz (ECCO)

07:45 - 16:00

07:45 - 16:00
Conference Registration

08:30 - 09:30

08:30 - 09:30	AM 1
Key Note Lecture Introduced by Mareike Ohms Malte Spielmann, University of Lübeck Lübeck, Germany Single cell sequencing and spatial transcriptomics – powerful tools to unravel pathophysiological pathways in inflammatory diseases

AM 1

09:30 - 11:30

09:30 - 11:30	AM S1, 3, 4
Poster session 2 (with coffee and snacks)

AM S1, 3, 4

11:30 - 12:30

11:30 - 12:30	AM 1
Session 8 Complement genetics, structure and function
Chairs: Elena Goicoechea de Jorge, Véronique Frémeaux-Bacci

AM 1

O30

The natural history of congenital genetic CD59 deficiency

Dror Mevorach, Netanel Karbian, Marian Zeibak, Adi Tabib

O31

Structural and functional characterization of mouse Factor H related B (FHR-B) protein

Silvia González Sanz, Adrián Martín-Ambrosio Doménech, Lucía Juana López, Santiago Rodríguez de Córdoba, Héctor Martín Merinero

O32

Lectin pathway inhibitor, ITIH4, forms stable, inhibitory complexes with catalytic fragment of MASP-1 through comprehensive domain reorganisation

Martin Høgholm Jørgensen, Ana Casañal, Steffen Thiel, Gregers Rom Andersen

O33

Targeted binding and activation of native C3 without proteolytic cleavage induced by contact with biosurfaces

David Eikrem, Vivek Anand Manivel, Anna Adler, Osama Hamad, Roland Ebert, Yuji Teramura, Camilla Mohlin, Kristina Ekdahl, Karin Fromell, Bo Nilsson

12:30 - 13:15

12:30 - 13:15	AM 1
Lunch Seminar SVAR Svar Life Science, not just another vendor

AM 1

12:30 - 13:30

12:30 - 13:30
Lunch

13:30 - 15:00

13:30 - 15:00	AM 1
Awards

AM 1

SVAR Awards

ECN Medal Awards

15:00 - 16:00

15:00 - 16:00
Session 9 Innovations in complement therapeutics and gene expression studies
Chairs: Trent Woodruff, Simon Clark

AM 1

O34

RBD7007 a potent siRNA compound for therapeutic reduction of hepatic and circulatory levels of C5

Anna Granqvist, Zhongguo Fu, Ke Ma, Xu Yan, Huiqing Cao, Shuquan Zheng, Hongyan Zhang, Zicai Liang, Shan Gao, Liming Gan

O35

Changes of complement profile after adeno-associated virus (AAV)-9 based gene therapy

Borbála Mikos, György Velkey, Lisa Hurler, György Sinkovits, Zoltán Prohászka

O36

Fantastic drugs and where to find them: investigating and improving drug-like properties of the leech-derived complement inhibitor gigastasin

Aleksandra Blagojevic, Peter Ruethemann, Said Rabbani, Alexander John Lander, Martin Smiesko, Kirsten Guse, Rolf Spirig, Markus Lill, Daniel Ricklin

O37

Characterisation of complement gene expression in human hippocampus

Van Dien Nguyen, You Zhou, Matthew Bright, B. Paul Morgan, Wioleta M. Zelek

16:00

16:00
End of Scientific Program Day 4

18:00 - 00:00

18:00 - 00:00
Hanseatic Dinner at the Maritim Travemünde

07:45 - 16:00

07:45 - 16:00
Conference Registration

08:30 - 09:30

08:30 - 09:30	AM 1
Key Note Lecture Introduced by Yves Laumonnier Henrik Oster, University of Lübeck Lübeck, Germany Circadian clocks – gatekeepers of health and disease

AM 1

09:30 - 10:30

09:30 - 10:30	AM 1
Session 10 Intracellular complement functions
Chairs: Peter Garred, Felix Poppelaars

AM 1

O38

Novel roles of intracellular C3 in inflammation

Katarzyna Kuska, Serena Bettoni, Frida Mohlin, Saleh Moradi, Maja Chrobak, Kristian Riesbeck, Ben King, Anna Blom

O39

Old C3 variants shed new light on the extracellular/intracellular C3 paradox

Daniel Chacon-Arguedas, Iván E. Benito, Ana V. Marín, Agustin Tortajada, Ben C. King, Anna M. Blom, José R. Regueiro

O40

An enemy within: Intracellular complement Factor H fuels tumor progression via cell cycle acceleration and enhanced energy metabolism

Mikel Rezola Artero, Andrea Minery, Margot Revel, Angela Armento, Mohamed-Ali Jarboui, Herve Fridman, Marius Ueffing, Lubka Roumenina

O41

Compstatins abolish pathogenic fibroblast function associated with inflammatory tissue priming

Jasna Friscic, Xi Chen, Sven Geisler, Dimitrios C Mastellos, John Lambris, Markus Hoffmann

10:30 - 11:00

10:30 - 11:00
Coffee Break

11:00 - 12:00

11:00 - 12:00	AM 1
Session 11 Complement in non-communicable diseases
Chairs: Lubka Roumenina, Ruben Pio

AM 1

O42

Conditional C3 knockout mice to study the impact of complement deficiency on neuroinflammation and Alzheimer’s disease pathology

Pieter Dujardin, Joyce Foroozandeh, Marlies Burgelman, Elien Van Wonterghem, Griet Van Imschoot, Clint De Nolf, Lien Van Hoecke, Charysse Vandendriessche, Roosmarijn Vandenbroucke

O43

Dysregulation of the complement alternative pathway is a major driver of kidney disease in an experimental model of MPO-associated vasculitis

Laura Lucientes Continente, Lucia Juana López, Marina Alonso Riaño, Alejandro Chozas Hernández , Santiago Rodríguez de Córdoba, Elena Goicoechea de Jorge

O44

C1-inhibitor is a novel prognostic factor in malignant pleural mesothelioma and in serous ovarian carcinoma

Andrea Balduit, Alessandro Mangogna, Chiara Agostinis, Federica Torricelli, Francesco Salton, Cristina Bottin, Gabriella Zito, Alessia Ciarrocchi, Fabrizio Zanconati, Marco Confalonieri, Giuseppe Ricci, Roberta Bulla

O45

Cell-intrinsic expression of C3 in pancreatic beta-cells is required for normal glucose homeostasis under metabolic pressure

Ben King, Lucie Colineau, Julia Slaby, Olga Kolodziej, Malin Fex, Anna Blom

12:00 - 12:25

12:00 - 12:25	AM 1
ECN General Assembly

AM 1

12:25 - 12:55

12:25 - 12:55	AM 1
EMCHD2024 poster & oral presentation prices

AM 1

12:55 - 13:10

12:55 - 13:10	AM 1
Announcement EMCHD 2026 - Cardiff

AM 1

13:10 - 13:25

13:10 - 13:25	AM 1
Announcement ICW 2025 - Brisbane

AM 1

13:25 - 13:40

13:25 - 13:40	AM 1
Closing Remarks, Farewell

AM 1

13:40

13:40	Foyer
Pick up of Lunch Bags

Foyer

14:00 - 15:00

14:00 - 15:00	AM S2
ECN Board Meeting

AM S2

Plasma proteins facilitate the invasion of erythrocytes by Plasmodium falciparum merozoites

Timo Reiß, Alliyah Byrd, Shery S.K. Ayoub, Gabriele Pradel

Unveiling the ancient interplay between the complement system and the Mycobacterium tuberculosis

Mario Alejandro Duque Villegas, Kerstin Walter, Christoph Hölscher

CORVOS – A model for PhD student exchanges and a European Complement PhD

Silke Huber, Marco Grasse, Doris Wilflingseder, Jörg Köhl, Stefan Niemann, Christoph Hölscher, Anna Blom, Cecilia Garlanda, Suzan H.M. Rooijakkers, Seppo Meri, Veronique Fremeaux-Bacchi, Peter Garred, Tom Eirik Mollnes, Zoltan Prohaszka, Reinhard Würzner

The effect of Streptococcus pneumoniae associated hemolytic uremic syndrome on glycosylation and endothelial complement activation

Laura M. Baas, Hans J. Wessels, Kes H. Stevens, Lieke ter Steeg, Jeroen D. Langereis, Kioa L. Wijnsma, Nicole C.A.J. van de Kar, Dirk J. Lefeber, Lambertus P. van den Heuvel

Differential complement activation and cytokine release in response to A. fumigatus and C. albicans incubated in human whole blood

Beatrice Fagerang, Maximilian Götz, Camilla Schjalm, Karin Ekholt McAdam, Verena Harpf, Anne Rosbjerg, Tom Eirik Mollnes, Peter Garred

The axis complement - Malassezia in Pancreatic Ductal Adenocarcinoma: local complement expression and fungal opsonization in pancreas

Cornelia Speth, Carmen Mathis, Reinhard Würzner, Gudrun Thurner, Georg Schäfer, Ruben Bellotti, Manuel Maglione, Günter Rambach

The axis complement - Malassezia in Pancreatic Ductal Adenocarcinoma: modification of yeast opsonization and viability by pancreatic environment

Günter Rambach, Carmen Mathis, Reinhard Würzner, Gudrun Thurner, Georg Schäfer, Ruben Bellotti, Manuel Maglione, Cornelia Speth

Complement activation in COVID-19, the role of soluble complement regulators

Stef van der Meulen, Leendert Trouw

Collectin-11 neutralizes SARS-CoV-2 spike protein: Implications for viral pathophysiology and lectin complement pathway dynamics

Adrian Sutta, Beatriz González-García, Laura Peréz-Alós, Anne Rosbjerg, Rafael Bayarri-Olmos, Peter Garred

P10

A newly designed antifungal drug candidate exploiting the non-canonical interaction between MASP-1 and A. fumigatus

Anne Rosbjerg, Verena Harpf, Ida Sandau Pedersen, Rafael Bayarri-Olmos, Mikkel-Ole Skjoedt, Cornelia Speth, Günter Rambach, Reinhard Würzner, Peter Garred

P11

Impact of serum in the integrity of the Mycobacterium tuberculosis cell wall

Mario Alejandro Duque Villegas, Kerstin Walter, Christoph Hölscher, Yan Tsun Abigail Lau

P12

Combined complement C3 and CD14 inhibition reduce Escherichia coli-induced thromboinflammation in the presence and absence of antibiotics

Ingrid Sofie Joakimsen, Baard Ove Karlsen, Åse Eeg Emblem, Kristin Pettersen, Renathe Henriksen Grønli Henriksen Grønli, Tom Erik Mollnes, Ole Lars Brekke

P13

Multiplex analysis of pneumococcal vaccine response in C2 deficiency

Christina Hansson, Lillemor Skattum

P14

Examining the Clinical and Complement Biomarker Profiles in C3 Glomerulopathy Patients Treated with Targeted Complement Inhibitors

Lauren Fergus, Jillian Hall, Nicole Gerot, Matthew Allen, Monica Hall, Patrick Walker, Yuzhou Zhang, Richard Smith, Carla Nester

P15

35 years of human complement inhibition – how it all began

Reinhard Würzner

P16

The story of empasiprubart (ARGX-117), an inhibitory C2 antibody with sweeping properties, from healthy volunteers to three phase 2 proof-of-concept studies

Kevin Budding, Karen De winter, Laura Bracke, Tim Delahaye, Jolien Delaere, Yasmine Driege, Emma Persson, Eline Haspeslagh, Ans Rombout, Inge Van de Walle

P17

Moss-produced human complement factor H (CPV-104) for clinical use as regulator of unbalanced complement in complement mediated diseases

Todor Tschongov, Swagata Konwar, Karsten Häffner, Mandy Hector, Anne Wolf, Thomas Langmann, Andreas Busch, Andreas Schaaf, Paulina Dabrowska-Schlepp

P18

INCREASED RISK OF EXTRAVASCULAR AND BREAKTHROUGH HEMOLYSIS IN CHILDREN AND ADOLESCENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA

Sara Graciaa, Nabil Saleem, Patricia McElfresh, Staci Arnold, Michelle Schoettler, Michael Briones, Satheesh Chonat

P19

INF904, a novel oral C5a Receptor 1 (C5aR1) antagonist, shows promising therapeutic effects in inflammatory disease models

Zhongli Xu, Rui Liu, Ophelia Chen, Bruce P. Burnett, Maria Habel, Renfeng Guo

P20

Preclinical pharmacological Characterization of INF904, an oral small molecule antagonist to complement 5a receptor1 (C5aR1)

Rui Liu, Zhongli Xu, Ophelia Chen, Bruce P. Burnett, Maria Habel, Renfeng Guo

P21

Altered complement response pattern within major cardiac surgery

Lisa Wohlgemuth, Dominik Hüsken, Pascal Max Lucien Lessing, Alexander Sebastian Koller, Darko Jovanovski, Anke Julia Schultze, David Alexander Christian Messerer, Markus Huber-Lang, Marco Mannes

P22

Design and Evaluation of Glycomimetics as Ficolin-1 Antagonists

Said Rabbani, Oliver Schwardt, Daniel Ricklin

P23

Irradiated apoptotic peripheral blood mononuclear secretome (APOSEC) attenuates complement activation in an in vitro xenotransplantation model

Neda Salimi-Afjani, Alain Despont, Michael Mildner, Hendrik Jan Ankersmit, Robert Rieben

P24

An ex vivo C3 convertase assay to evaluate the effectiveness of factor D inhibition in vivo in patients with C3 glomerulopathy (C3G)

Roberta Donadelli, Erica Daina, Sara Gamba, Ariela Benigni, Giuseppe Remuzzi, Marina Noris

P25

Sustained terminal complement inhibition on endothelium with ravulizumab in patients with atypical hemolytic uremic syndrome

Sistiana Aiello, Sara Gastoldi, Elena Bresin, Roberta Donadelli, Ariela Benigni, Giuseppe Remuzzi, Marina Noris

P26

Complement-mediated renal diseases after kidney transplantation: a natural history study in idiopathic membranoproliferative glomerulonephritis (MPGN)

Carolina Martinatto, Maddalena Marasà, Giliane Nanchen, Matteo Breno, Miriam Rigoldi, Marina Noris, Elena Bresin, Sara Gamba, Laura Bottanelli, Zahra Imanifard, Rossella Piras, Roberta Donadelli, Caterina Mele, Ariela Benigni, Giuseppe Remuzzi, Erica Daina

P27

Mechanism of breakthrough haemolysis in PNH patients under C3 inhibition

Hiba Ghaboosh, Marco Mannes, Jannik Sichau, Alina Dettner, Britta Höchsmann, Admar Verschoor, Markus Huber-Lang, Richard Kelly, Daniel Ricklin, Christoph Schmidt

P28

Activation of complement is associated with proteinuria in pediatric kidney transplantation

Lou Barbier, Adrien Flahault, Alexandra Cambier, Anne-Laure Lapeyraque

P29

Trends in Complement Pathway Biomarkers Before and After Eculizumab Initiation in C3 Glomerulopathy

Tina Liu, Monica Hall, Patrick Walker, Yuzhou Zhang, Richard Smith, Carla Nester

P30

High prevalence of the complement factor I p.Ileu357Met mutation in Tunisian aHUS patients

Asma Tajouri, Rimeh benbrahim, Hend Jlajla, Imen Ayadi, Yousr Zerzeri, Lilia Laadhar, Maryam Kallel Sellami

P31

Non-encapsulated Neisseria meningitidis sepsis in a paroxysmal nocturnal hemoglobinuria patient treated with the complement inhibitor pegcetacoplan

Leo Starck, Vuokko Nummi, Eira Poikonen, Anna Lehtinen, Pia Kivelä, Jukka Torvikoski, Nathalie Friberg, Maija Toropainen, Seppo Meri

P32

Circulating Immune Complexes in IgA Nephropathy

Ida Mariegaard, Laura Pérez-Alós, Jonathan Barratt, Peter Garred

P33

Factor H-Related Protein 1 in Systemic Lupus Erythematosus

Jessica Kleer, Juliane Klehr, Denise Dubler, Laura Infanti , Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg

P34

IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset

Danielle Krijgsman

P35

Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) as a Compensatory Protease Inhibitor in Hereditary Angioedema (HAE)

Anne Troldborg, Zsofia Godnic-Polai, László Cervenak, Annette G. Hansen, Henriette Farkas, Steffen Thiel

P36

A cell-based assay to measure the activity of the complement convertases

Malgorzata Stasilojc, Grzegorz Stasilojc, Alicja Kuzniewska, Santiago Rodriguez de Córdoba, Marcin Okrój

P37

Complement Activation, Neutrophil Extracellular Traps and Extracellular DNA Associate with Worse Survival in Epithelial Ovarian Cancer Patients

Bert R.J. Veuskens, Jason Ricciuti , Qian Liu, ANM Nazmul H Khan, Janine Joseph, Thejaswini Giridharan, Sora Suzuki, Tiffany R. Emmons, Michael B. Yaffe, Mieke C. Brouwer, Emese Zsiros, Ilse Jongerius, Taco W. Kuijpers, Richard B. Pouw, Kirsten B. Moysich, Brahm H. Segal

P38

A Comparative Analysis of Nef Activity using Distinct Assays: Hemolysis vs SPR

Christopher Culek, Renee Goodfellow, Nic Meyer, Yuzhou Zhang, Richard Smith, Carla Nester

P39

Urinary sC5b-9 levels predict residual renal function reservation in peritoneal dialysis patients

Masashi Mizuno, Aki Oshima, Keiko Higashide, Masafumi Suzuki, Sosuke Fukui, Yasuhiro Suzuki, Hangsoo Kim

P40

Novel antibodies and assays to ascertain the role of C4 protein variants in Schizophrenia risk

Kirsten Baillie, Robert A J Byrne, Erik J M Toonen, Laura Westacott, B Paul Morgan, Wioleta M Zelek

P41

Development of assays to allow personalized dosing of CAD patients with Sutimlimab

Kyra Gelderman, Angela Kamp, Kathelijn Verdeyen, Esther de Boer, Floris Loeff, Theo Rispens, Richard Pouw, Josephine Vos

P42

Precise immunohistochemical visualization of C4d complement fragment using C-terminal linear neoepitope-specific antibodies

Daria Kowalska, Micha? Bie?kowski, Paulina Jurkowska, Ada Kawecka, Jacek Kury?o, Alicja Ku?niewska, Anna M. Blom, Marcin Okrój

P43

Biomarker signatures in plasma and plasma-derived exosomes implicate complement in frontotemporal dementia

Lewis Watkins, Paul Morgan, Aitana Sogorb-Esteve, Wioleta Zelek

P44

Relation between binding epitope and complement activity of anti-PLA2R1 autoantibodies from patients with membranous nephropathy

Sara Montagner, Marco Catalano, Linda Reinhard, Alexandra Lavoisier, Raviraj Kulathila, Zheng Zhou, Martine Marchant, Mariavittoria Iazeolla, Nathalie Welker, Elion Hoxha, Elisabetta Traggiai

P45

Reduced levels of C5a Complement Receptor Antibodies are linked to Relapse in Eosinophilic Granulomatosis with Polyangiitis (EGPA)

Sebastian Klapa, Sabrina Arnold, Antje Müller, Andreas Koch, Anja Staehle, Wataru Kähler, Harald Heidecke, Gabriela Riemekasten, Peter Lamprecht

P46

Familial deficiency of the C2 component of complement

Olivera Savic, Ivana Jaglicic

P47

Complement Activation in Renal Thrombotic Microangiopathy

Meng Tan, Ying Tan, Xiaotian Liu

P48

An immunoassay to determine the complement activation by systemic lupus erythematosus immune complexes

Sanjay Khandelwal, Jonah Chen, Sooho Myoung, Grace Lee, Samuel Francis, Jennifer Rogers, David Pisetsky, Gowthami Arepally

P49

An immunoassay to study alternative complement pathway activity in plasma

Boglár Gál, Laura Pérez-Alós, Ida Mariegaard, Beatrice Fageräng, Anne Rosbjerg, Tom Eirik Mollnes, Peter Garred

P50

Tumor suppressor role of the complement inhibitor CSMD1 and its role in TNF-induced neuroinflammation in gliomas

Emre Can Tuysuz, Eleni Mourati, Rebecca Rosberg, Aleksandra Moskal, Chrysostomi Gialeli, Karolina Smolag-Klosowska, Elinn Johansson, Valeria Governa, Mattias Belting, Alexander Pietras, Anna Blom

P51

Development and characterization of novel ELISAs for the specific quantification of the Factor H-related proteins 2, 3, 4 and 5

Mara van Rossum, Bert R.J. Veuskens, Mieke C. Brouwer, Antje J. Baumner, Laura Lucientes-Continente, Elena Goicoechea de Jorge, Barbara Uzonyi, Alexandra T. Matola, Mihály Józsi, Günter Müller, Felix Poppelaars, Diana Pauly, Richard B. Pouw, Erik Toonen

P52

Development of a multiplex point-of-care-test to improve diagnosis and treatment of complement-mediated kidney diseases

Bregje van Bree, Bertina Mülleder, Johanna Grabner, Kes Stevens, Nicole C. A. J. van de Kar, Lambertus van de Heuvel, Nikolaus Ladenhauf, Max Sonnleitner, Erik Toonen

P53

Complement activation in anti-phospholipid syndrome

Houcine Hamidi, Cecile Yelnik, Marc Lambert, Marie-Sophie Meulemann, Anna Duval, Sonia Chemlal, Alain Gey, Stéphane Roncelin, Clemence Granier, Veronique Fremeaux-Bacchi, Lubka Roumenina, Eric Hachulla, Marie Frimat, Luc Darnige, Marie Agnès Dragon Durey

P54

Complement function and activation in differentially collected human serum and plasma

Linnea I. Andersson, Dick J. Sjöström, Ricardo JMGE Brandwijk, Erik J. M. Toonen, Tom Eirik Mollnes, Per H. Nilsson

P55

Complement activation in patients with ANCA-associated vasculitis in remission

Rebecca Trattner, Maria Iordanou, Myriam Martin, Mårten Segelmark, Anna Blom

P56

Quantification of levels of Factor H family proteins in Covid-19 convalescent plasma samples

Barbara Uzonyi, Alexandra T. Matola, Eszter Gyetvai, Luca E. Tóth, János Nacsa, Eszter Fodor, Zsombor Lacza, Richard B. Pouw, Erik J.M. Toonen, Mihály Józsi

P57

Blood Factor Bb as a Reliable Indicator for Post-Xenotransfusion Complement Activation

Hee Jung Kang, Juhye Roh, Haneulnari Lee, Eun Mi Park, Hye Won Lee

P58

Novel – in part patented and/or commercialized – assays to determine early/late complement activation and murine C5aR2 expression under the umbrella of CORVOS

Lisa Hurler, Mariam Massri, Janti Haj Ahmad, Jörg Köhl, Zoltán Prohászka, Silke Huber, Reinhard Würzner

P59

Nephritic Syndrome with Hypocomplementemia

Charan Bale, Chetan Phadke, Atul Sajgure, Tushar Dighe, Pavan Wakhare, Nilesh Shinde

P60

Evaluation of urinary FHR-2, FHR-3, FHR-4, and FHR-5 levels and their potential as biomarkers of disease activity in ANCA-associated vasculitis

Jousef A. Issa, Alejandro Chozas Hernández, Laura Lucientes-Continente, Richard B. Pouw, Erik J.M. Toonen, Gema Fernandez-Juarez, Elena Goicoechea de Jorge

P61

Potential Diagnostic and Prognostic Complement Markers in Head and Neck Cancer

Nicole Schäfer, Sina Franziska Heimer, Denis Vlasow, Lisa Marie Schmidt, Tobias Ettl, Richard Josef Bauer

P62

Complement regulators CD55 and CD59 are differentially distributed during red blood cell enucleation

Esther C. W. de Boer, Astrid J.F. Thielen, Anna Visser, Angela Kamp, Diana Wouters, Patrick Burger, Simon Tol, Nurcan Yagci, Marieke M. von Lindern, Emile van den Akker, Ilse Jongerius, Richard Pouw

P63

Target neutrophil extracellular traps reducing complement-mediated thrombotic microangiopathy

Ying Tan, Minghui Zhao

P64

Characterizing a potential third class of C3 nephritic factors in patients with complement-mediated kidney diseases

Kes H. Stevens, Rianne J. F. Maas, Elena B. Volokhina, Marnix Ponfoort, Nicole C. A. J. van de Kar , Lambertus P. W. J. van den Heuvel , Marloes A. H. M. Michels

P65

The role of complement system in platelet transfusion refractoriness

Susa Savukoski, Marco Mannes, Anke Schultze, Lisa Wohlgemuth, Markus Huber-Lang

P66

Light chain amyloid proteins initiate complement activation in ex vivo models of serum, plasma, and whole blood

Viktoriia Chaban, Elin Roscher, Emilie I. Anderson, Christopher J. Dick, Pinaki Misra, Tom Eirik Mollnes, Taxiarchis Kourelis, Søren Erik Pischke

P67

Retrospective evaluation of complement components and activation products measurements in patients with age-related macular degeneration in a diagnostic setting

Mahfam Shahabi, Yara Lechanteur, Francesco Cinque, Caroline Klaver, Bert van den Heuvel

P68

Targeted Assault: Mechanisms of Surface-Specific Complement Activation via the Alternative Pathway

Elod Kortvely, Kevin Widmer, Corinne Stucki, Ewelina Golec, Richard Schreurs

P69

Only a low amount of Factor D is required to modulate membrane-dependent complement homeostasis

Xiaobo Wu, Zheng Hu, Thomas Xu, John Atkinson

P70

Contact system activation and C5a generation by follow-on products of pentosan polysulfate, but not by the original drug substance

Susanne Alban, Cornelia Rodde, Marie-Theres Tischhöfer

P71

A new role for MASP-1 in endothelium-dependent vascular responses

Nóra Melinda Kerkovits, Dorina Nagy, Éva Ruisanchez, Péter Tibor Dancs, László Hricisák, Mónika Kosztelnik, József Dobó, Gábor Pál, László Cervenak, Gábor József Tigyi, Péter Gál, Morley Donald Hollenberg, Zoltán Benyó

P72

Complement activation: a key mediator in the pathogenesis of anti-p200 pemphigoid

Shirin Emtenani, Charlotte Kiehne, Tina Rastegar Lari, Meike Holtsche, Enno Schmidt

P73

A fusion protein of the two tick-derived C5 inhibitors OmCI and RaCI: complete C5 inhibition despite strong complement activation

Sümeyye Erdemci-Evin, Verena Kaupper, Arthur Dopler, Elsa Dopler, Christoph Q. Schmidt

P74

In C3G/IC-MPGN, C3 activation products target podocyte cell surface and alter podocyte structure

Simona Buelli, Rossella Piras, Roberta Donadelli, Zahra Imanifard, Caterina Mele, Elena Bresin, Miriam Rigoldi, Giuseppe Remuzzi, Marina Noris, Ariela Benigni

P75

Involvement of Alternative C5-Convertases in Inducing Skin Inflammation in Experimental Pemphigoid Diseases

Sadegh Mousavi, Sören Dräger, Leon Schmidt-Jiménez, Mayumi Kamaguchi, Kentaro Izumi, Anika Kasprick, Sabrina Patzelt, Shirin Emtenani, Manuela Pigors, Enno Schmidt, Katja Bieber, Ralf Ludwig

P76

The immunological effect of multigene modifications in transgenic porcine endothelial cells under inflammatory xenotransplantation conditions

Cedric Zimmermann, Alain Despont, Jane Shaw, Angelika Schnieke, Konrad Fischer, Robert Rieben, Mitra Gultom

P77

Alzheimer’s disease-associated complement receptor 1 variant impacts glial functions

Nikoleta Daskoulidou, Bethany Shaw, Wioleta M. Zelek, B. Paul Morgan

P78

Ectopic expression of mature- but not pro-factor D in the mouse liver causes C3-dependent factor B depletion with therapeutic potential

Hangsoo Kim, Damodar Gullipalli, Takashi Miwa, Madhu Golla, William Halle, Sayaka Sato, Wen-Chao Song

P79

THE ROLE OF FACTOR H AND THE FACTOR H-RELATED PROTEINS FHR-1 AND FHR-5 IN NECROTIC CELL CLEARANCE

Andrea Espárné Schneider, Babett Nagy, Mihály Józsi, Dániel Bencze

P80

FACTOR H-RELATED PROTEINS MODULATE COMPLEMENT ACTIVATION VIA THE C3 CONVERTASE

Barbara Uzonyi, Alexandra Tünde Matola, Dániel Bencze, Dávid Szakács, Mihály Józsi

P82

Complement activation in Tauopathies

Jacqui Nimmo, Samuel Keat, Lewis Watkins, Megan Torvel, Louis De Muynck, B. Paul Morgan

P83

C3b- and C5-inhibiting nanobodies: from llama immunization to molecular characterization

Eva M. Struijf, Jamie S. Depelteau, Karla I. De La O' Becerra, Fleur van Oosterom, Joanne E. van Keulen, Danique Y. Siere, Maartje Ruyken, Carla J.C. de Haas, Dani A.C. Heesterbeek, Gillian Dekkers, Edward Dolk, Raimond Heukers, Bart W. Bardoel, Piet Gros, Suzan H.M. Rooijakkers

P84

Bispecific antibodies targeting C1q and a tumor antigen activate the complement system independent of C1q-Fc interactions

Douwe Dijkstra, Els van der Meijden, Frank Beurskens, Leendert Trouw

P85

Complement C4d deposition in interlobular arteries is associated with patient’s age and interstitial fibrosis in newly diagnosed ANCA-associated renal vasculitides

Eva Baier, Samy Hakroush, Björn Tampe

P86

Bone marrow emboli following porcine femoral nailing triggered inflammation with blood IL-6 increase and complement activation in heart and lungs

Steinar Kristiansen, Benjamin Stage Storm, Åse Eeg Emblem, Renathe Henriksen Grønli, Kristin Pettersen, Jonas Hilmo, Anders Hagen Jarmund, Martin Leth-Olsen, Siri Ann Nyrnes, Bent Aksel Nielsen, Erik Waage Nielsen, Tom Eirik Mollnes

P87

Novel interaction between MASP-3 and IGF-binding proteins

Tereza Alica Plchová, Anne Rosbjerg, Laura Pérez-Alós, Peter Garred

P88

Protein array screening reveals potential new interaction partners of ficolin-3

Linnea Lindelöf, Roland Ebert, Oskar Eriksson

P89

Complement factor C5 is not essential in Escherichia coli-induced platelet aggregation in human whole blood

Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Bård Ove Karlsen, Tom Eirik Mollnes, Per H. Nilsson, Ole-Lars Brekke

P90

Complement factor H influences plasma clot structure and fibrinolysis

Soutiam Goodarzi, Jeries Abu-Hanna, Nicola Curry, Meike Heurich

P91

Development of potent and selective agonists for C5a receptor 2

Joshua Dent, Sam Gibson, Richard Clark

P92

Titration of the Anaphylatoxins biologicals activities

Christophe Lallemand, Emilie Gobbo, Caroline Grygar

P93

Targeting Classical Complement Components in Sepsis-Associated Encephalopathy (SAE)

Özge Candemir, Nina Hahn, Ha-Yeun Chung , Jonathan Wickel, Meike Schwarzbrunn, Stephan Steinke, Michael Hust, Christine Skerka, Christian Geis

P94

C5aR1 Tracking and Fate Mapping in Dendritic Cell Populations

Mareike Ohms, Elvira Ehlers-Jeske, Gabriele Köhl, Jörg Köhl

P95

Role of anaphylatoxin receptors C5aR1 and C5aR2 in hypertension and hypertensive end organ damage

Leonie Dreher, Sarah Walachowski, Georg R. Herrnstadt, Nicolas Ehnert, Catherine Meyer-Schwesinger, Jörg Köhl, Tobias B. Huber, Markus Bosmann, Ulrich O. Wenzel

P96

Epithelial complement activation and anaphylatoxin receptor expression in murine respiratory air liquid interface culture

Janti Haj Ahmad, Doris Wilflingseder, Jörg Köhl

P97

Differential roles of C3aR and C5aR1 in hematopoietic stem cell differentiation and function of type 1 and 2 conventional dendritic cells

Alicja Anna Nowacka, Sven Geisler, Chandrashekhar Pasare, Jörg Köhl

P98

Angiotensin II Augments C3a Anaphylatoxin-Induced Vasoconstriction in the Murine Aorta

Imre Babay, Nóra Melinda Kerkovits, Csillag Virág Tóth, Balázs Besztercei, Ágnes Szappanos, Mónika Kosztelnik, Péter Sótonyi, Zoltán Benyó

P99

Omics-based investigation of C5aR2-deletion-induced pregnancy complications

Katja Kähler, Friederike Hapke, Christian Karsten

P100

The C5aR2 pathway as a potential novel checkpoint for B cell activation and differentiation

Jovan Schanzenbacher, Jörg Köhl, Christian M. Karsten

P101

Unraveling C5aR1 induced intracellular signaling driving thrombus formation on microvascular endothelial cells

Valeria Guaschino, Sara Gastoldi, Lorena Longaretti, Ariela Benigni, Giuseppe Remuzzi, Marina Noris, Sistiana Aiello

P102

Targeting the Hypothalamic Complement System: A Novel Approach to Combatting Obesity

Carolin Gragoll, Elias Rawish, Timo Rusack, Michael Schneider, Katharina Kurz, Thomas Stiermaier, Harald Langer, Markus Schwaninger, Jörg Köhl, Zouhair Aherrahrou, Ingo Eitel

P103

Cannabinoid receptor-1 antagonist MRI-1867 protects from C5aR1 signaling-mediated aberrant autophagic response in Collagen-Induced Arthritic Mice

Haydn Rich, Aleksey Domozhirov, Yi Dong Li, Tingting Weng-Mills, Madeline Jensen, Hari Yalamanchili, Eric Wagner, Malliga R. Iyer, Pooja Shivshankar

P104

Eosinophilic anaphylatoxin receptors expression profile differs according to their location in murine and human duodenum

Ifrat Ara, Ella von Arnim, Charlotte Heineking, Lea Kissing, Christian Sina, Yves Laumonnier

P105

IgM anti-GM1 antibodies and complement activation in an iPSC-derived disease model for multifocal motor neuropathy

Danielle Krijgsman

P106

Unveiling the enigmatic potential: nomacopan creates an organ-protective phenotype by protecting the damaged endothelial surface after traumatic hemorrhage in swine

Yansong Li, Miles Nunn, Amy Kim, Yansheng Feng, Milomir Simovic, Gabriel Jeppson, Chelsea Halcomb, Isai Garza-Chapa, Jacqueline Illario, Tatiana Corey, Leopoldo Cancio, Sander Hacker, James Elliott, James Bynum

P107

Role of Factor H Related Protein 1 in Age Related Macular Degeneration

Andjela Sekulic, Inga Marie Pompös, Luce Perie, Silvia Winkler, Kelly Mulfaul, Robert Mullins, Florian Sennlaub, Peter F. Zipfel, Christine Skerka, Olaf Strauß

P108

Towards gene therapy using HDM-FH: Testing in animal models of renal disease

Grace Mallett, Isabel Y. Pappworth, Grant J. Logan, Ian E. Alexander, David Kavanagh, Kevin J. Marchbank

P109

The C3 D1115N gain of function mutation protects Cfh+/- mice from nephrotoxic serum nephritis

Grace Mallett, Isabel Y. Pappworth, Harriet Denton, Nathan Simpson, Beth G. Gibson, Kate Smith-Jackson, David Kavanagh, Kevin J. Marchbank

P110

Absence of complement C3 exacerbates disease onset in experimental murine autoantibody-mediated autoimmune skin disease, while limiting disease progression

Leon F. Schmidt-Jiménez, Patricia Freire, Kentaro Izumi, Mayumi Kamaguchi, Katja Bieber, Ralf J. Ludwig, Admar Verschoor

P111

Complement Drives Lethal Acute Chest Syndrome in a Mouse model of Sickle Cell Disease

Satheesh Chonat, Jayre Jones, Seema Patel, Michelle Schoettler, Lauren Jeffers, Olufolake Adisa, Fang Tan, Earl Fields, Morgan Sterling, Ryan Jajosky, Sara Graciaa, Elisabetta Foppiani, Ross Fasano, Patricia Zerra, Yongzhi Qiu, Connie Arthur, Wilbur Lam, Solomon Ofori-Acquah, Michael Koval, Clinton Joiner, David Archer, Sean Stowell

P112

Development of a mouse model of severe ANCA vasculitis with both renal and pulmonary injuries

Damodar Gullipalli, Madhu Golla, Takashi Miwa, Lakshimi Poka , Sayaka Sato, Matthew Palmer, Wen-Chao Song

P113

Exploring the role of complement in regulating glutamate transmission at cortical synapses in mice suffering from Experimental Autoimmune Encephalomyelitis

Alice Taddeucci, Veronica Torre, Nicole Rosenwasser, Hanna Trebesova, Guendalina Olivero, Massimo Grilli, Anna Pittaluga

P114

Comparative Studies of Human and Rodent Complement Responses to Immune Complexes

Sanjay Khandelwal, Adrien Jacobs, John Mercer, V. Louise Roth, Brandon Garcia, Gowthami Arepally

P115

Beta2-targeted polymeric nanoparticles form a protective layer to prevent complement-mediated endovascular thrombosis in an anti-phospholipid syndrome model

Paolo Macor, Paolo Durigutto, Maria Cristina Grimaldi, Sara Bozzer, Francesco Tedesco, Pier Luigi Meroni

P116

Messenger-RNA-LNP COVID-19 vaccines activate complement and induce production of proinflammatory cytokines in PBMC cultures: mechanisms and relevance to adverse events

Tama?s Bakos, Tama?s Me?sza?ros, Gergely Tibor Kozma, Ga?bor Sze?na?si, Ja?nos Szebeni

P117

Eculizumab suppresses zymosan-induced release of inflammatory cytokines in autologous serum-substituted PBMC cultures: Relevance to cytokine storm in Covid-19

Tama?s Bakos, Tama?s Me?sza?ros, Gergely Tibor Kozma, Ga?bor Sze?na?si, Ja?nos Szebeni

P118

Escalated complement activation during hospitalisation is associated with higher risk of 60-days mortality in SARS-CoV-2 infected patients

Andreas Barratt-Due, Kristin Pettersen, Tuva Børresdatter-Dahl, Jan Cator Holter, Renathe H Grønli, Anne Ma Dyrhol-Riise, Tøri Vigeland Lerum, Aleksander Rygh Holten, Kristian Tonby, Marius Trøseid, Ole Henning Skjønsberg, Beathe Kiland Granerud, Lars Heggelund, Anders Benjamin Kildal, Camilla Schjalm, Trond Mogens Aaløkken, Pål Aukrust, Thor Ueland, Tom Eirik Mollnes, Bente Evy Halvorsen

P119

Characterization of inherited C3 deficiency – A patient case

Mari Humalajoki, Petteri Arstila, Merja Helminen, Pirkka Pekkarinen, Marjo Vuorela, Eija Nissilä, Inkeri Lokki, Seppo Meri

P120

A Genetic Insight: Factor H-related 1 in Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy

Amanda Slagle, Michael Jones, Nicole Meyer, Amanda Talyor, Nicolo Ghiringhelli Borsa, Yuzhou Zhang, Richard Smith

P121

Concentration and Distribution of FH and FHL-1 Proteins in Human Plasma and Ocular Tissues Stratified by Chromosome 1q32 Genotypes

Burt Richards, Robert Anstadt, Jin Liu, Marc Toso, Jennifer Mohler, Chris Pappas, Tana Corsetti, Nathan Seager, Stacie Matthews, William Hubbard, Julie Thomas, Jill Hageman, Moussa Zouache, Brandi Williams, Gregory Hageman

P122

Functional Evaluation of Variants in Complement Factor I: Insight from an In-Vitro Minigene Splicing Assay

Cobey Heinen, Nicolo Ghiringhelli Borsa, Amanda Taylor, Richard Smith, Yuzhou Zhang

P123

Complement polygenic risk score as a predictor of Alzheimer’s Disease

Samuel Keat, Atahualpa Castillo Morales, Rebecca Sims, Julie Williams, B. Paul Morgan, Sarah Carpanini

P124

Rare variants in genes coding for components of the terminal pathway of the complement system in preeclampsia

A. Inkeri Lokki, Michael Triebwasser, Emma Daly, FINNPEC Cohort, Mitja I. Kurki, Markus Perola, Kirsi Auro, Jane E. Salmon, Anuja Java, Mark Daly, John P. Atkinson, Hannele Laivuori, Seppo Meri

P125

Comprehensive functional characterization of Complement factor I rare variant genotypes identified in the SCOPE Geographic Atrophy cohort

Anneliza Andreadi, Thomas Hallam, Scott Sharp, Emanuela Gardenal, Anna Dreismann, Vicky Brocklebank, Andrew Lottery, Kevin Marchbank, Claire Harris, Amy Jones, David Kavanagh

P126

The role of Complement Factor I Rare Genetic Variants in Age Related Macular Degeneration in Finland

Anneliza Andreadi, Thomas Hallam, Scott Sharp, Vicky Brocklebank, Patrick Walsh, Tom Southeringnton, Marco Hautalahti, David Steel, Andrew Lottery, Claire Harris, Kevin Marchbank, Amy Jones, David Kavanagh

P128

pQTL analysis of ficolin-3 activity in patients with systemic lupus erythematosus

Linnea Lindelöf, Solbritt Rantapää-Dahlqvist, Christian Lundtoft, Johanna K Sandling, Dag Leonard, Ahmed Sayadi, Lars Rönnblom, Helena Enocsson, Christopher Sjöwall, Andreas Jönsen, Anders A Bengtsson, Mun-Gwan Hong, Lina-Marcela Diaz-Gallo, Matteo Bianchi, Sergey V Kozyrev, Kerstin Lindblad-Toh, Kristina Nilsson Ekdahl, Bo Nilsson, Iva Gunnarsson, Elisabet Svenungsson, Oskar Eriksson

P129

A Physician-based Brazilian Registry for Hereditary Angioedema: insights from the first 713 Patients

José Eduardo Seneda Lemos, Mariana Paes Leme Ferriani, Fernanda Leonel Nunes, Marina Mendonça DIas, Pedro Giavina Bianchi, Persio Roxo-Junior, Fernanda Gontijo Minafra, Gabriela Andrade Coelho Dias, Faradiba Sarquis Serpa, Therezinha Ribeiro Moyses, Fernanda Casares Marcelino, Jane da Silva, Mariana Rebeschini Figueiredo, Maria Stela Yunes Moraes, Herberto José Chong Neto, Nelson Augusto Rosário Filho, Caroline Guth de Freitas Batista de Moraes , Sarah Sella Langer, Rozana de Fátima Gonçalves , Lucca Nogueira Paes Jannuzzi , Régis de Albuquerque Campos , Joanemile Pacheco De Figueiredo, Joice Trigo da Fonseca , Marcelo Vivolo Aun, Ana Julia Ribeiro Teixeira, Ana Paula Beltran Moschione Castro, Nayara Maria Furquim Nasser, Eliana Toledo, Iramirton Figuerêdo Moreira , Solange Oliveira Rodrigues Valle, Maria Luiza Oliva Alonso, Eli Mansour, Adriana Azoubel Antunes , Natasha Rebouças Ferraroni, Leonardo Oliveira Mendonça, Janaira Fernandes Severo Ferreira, Albertina Varandas Capelo , Alex Isidoro Ferreira Prado, João Bosco Pesquero, Priscila Nicolicht de Amorim , Konrad Bork, Sven Cichon, Anne Marielle Camargo, Fabianne Leticia Lopes, Maria Eduarda Trocoli Zanetti, Orlando Trevisan Neto, Luana Sella Motta Maia , Fabiola Traina, Adriana Santos Moreno, Maite Lobo Kolarik, Davi Casale Aragon, Natalia Dias Melo, Luisa Karla Arruda, Anete Sevciovic Grumach

P130

Identification of a Novel Intronic Variant in the Complement Factor I Gene

Simon Peter Nagy, Sarolta Dobner, Léna Szabó, Ádám Goschler, Zoltán Prohászka, Ágnes Szilágyi

P131

Molecular mapping of monoclonal antibodies binding complement C5

Rebekah Cooke, Georgina Menzies, B Paul Morgan, Wioleta M Zelek

P132

Mechanistic insights into complement pathway inhibition by duplication of Complement Receptor 1 (CR1) long homologous repeat domains

Sandra Wymann, Anup Nair, Svenja Ewert, Glenn Powers, Adriana Baz Morelli, Tony Rowe, Matthew Hardy

P133

Computer-aided Design of Complement C1s-C4 Inhibitors targeting Schizophrenia

Marika Zuanon, Marcella Bassetto, Meike Heurich

P134

Functional characterization of complement Factor H CCP19-20 variants with a set of host-derived and microbial ligands

Dániel Bencze, Martina Valéria Sajgó, Dávid Szakács, Barbara Uzonyi, Mihály Józsi

P135

An alternative and rapid small scale C3b purification method

Jannik Sichau, Arthur Dopler, Christoph Schmidt

P136

Development of liposomes as biomimics to study the complement system

Ferdinand Holzhausen, Clemens Spitzenberg, Antje J. Baeumner

P137

Breaking the boundaries of the clinical C3 inhibitor compstatin: Development of species-tolerant and long-acting analogs

Stephanie Vogt, Alexander John Lander, Roman Aschwanden , Christina Lamers, Oliver Schwardt, Brian Geisbrecht, Henriette Meyer zu Schwabedissen, Markus Lill , John Lambris, Martin Smieško, Daniel Ricklin

P138

Increased thromboinflammatory load in hereditary angioedema

Olav Rogde Gramstad, Camilla Schjalm, Tom Eirik Mollnes, Erik Waage Nielsen

P139

Comprehensive Immunogenicity Analysis of AAV Therapies: Correlating Anti-AAV Antibodies (NAbs/TAbs) with Complement Activation Dynamics

Klaudia Kulak, Samuel Butler, Selvi Celik, Viktoria Kozma, Cecilia Klint, Benoit Vallette, Camilla Nilsson, Christoffe Lallemand, Michael Tovey, Jordi Rodo, Michael Schwenkert

P140

Elucidating Complement Activation Mechanisms in AAV Gene Therapy: Development of a Novel ELISA-Based Assay for Enhanced Safety and Efficacy

Klaudia Kulak, Samuel Butler, Viktoria Kozma, Cecilia Klint, Camilla Nilsson, Michael Schwenkert, Michael Tovey, Jordi Rodo

P141

Reporting of a novel interaction between complement factor I and HTRA1

Franziska Woerz, Sarah de Jong, Damla Ayyildiz, Klaudija Masarini, Alexander Tschulakow, Burda Antonina, Sylvie Julien-Schraermeyer, Franziska Klose, Katrin Dahlke, Mohammed Al Jarboui, Karsten Boldt, Caroline Klaver, Anna Blom, Jannik Sichau, Christoph Q Schmidt, Alan Wright, Michael Ehrmann, Marius Ueffing, Simon J Clark

P142

Towards Multi-Pathway Regulatory Peptides: Leech-Derived Bivalent Inhibitors of Host-Defence Proteases

Alexander John Lander, Aleksandra Blagojevic, Peter Rüthemann, Stephanie Anita Vogt, Oliver Schwardt, Daniel Ricklin

P143

Roles of PTX3 in clearance of SARS-CoV-2 via macrophage phagocytosis of infected epithelial cells

Hang Zhong, Matteo Stravalaci, Isabel Pagani, Niloufar Kavian-Tessler, Domenico Supino, Francesco Scavello, Ilya Belevich, Barbara Bottazzi, Poli Guido, Andrea Doni, Elena Magrini, Sarah Mapelli, Seppo Meri, Cecilia Garlanda

P144

Development of a platform for the expression of recombinant antibodies targeting complement proteins

Florian Meyer, Aleksandra Blagojevic, Ekaterina Umnyakova, Richard B. Pouw, Said Rabbani, Daniel Ricklin

P145

Comprehensive Profiling of Cell Type-Specific Expression and Distribution of Complement Genes in Mouse and Human Kidneys

Xianzhi Li, Li Zhu

P146

Blood glucose homeostasis and identification of a CD59ba hybrid transcript in a CD59 double knockout mouse model

Alexander Ekström, Ben King, Anna Blom

P147

Intracellular C1r promotes kidney cancer progression

Nicolas Merle, Mikel Rezola Artero, Alessandra Zarantonello, Artemis Angelidou, Margot Revel, Idris Boudhabhay, Christine Gaboriaud, Lubka Roumenina

P148

Oxidative stress and intracellular anaphylatoxin receptor activation control Ca2+ homeostasis in RPE cells by augmenting ER Ca2+ uptake and ER-mitochondrial Ca2+ transfer

Baerbel Rohrer, Masaaki Ishii

P149

Noncanonical Functions of Local and Intracellular CFH in Choroid Endothelial Cells

Aarin Jones, Dominic Vergata, Sean D'Italia, Ying Hu, Botir Sagdullaev

P150

Flow-based Indirect Antiglobulin Test demonstrates complement activation by autoimmune hemolytic anemia IgM, but not IgG – observations from the DRAIHA study

Esther C. W. de Boer, Femke Mulder, Angela Kamp, Marit Jalink, Mieke Brouwer, Ilse Jongerius, Theo Rispens, Kyra Gelderman, Claudia Folman, Masja de Haas, Josephine M. I. Vos, Richard B. Pouw

P151

Terminal complement complex as potential inducer of premature senescence in age- and trauma-related osteoarthritis

Leonie Ruths, Jana Hengge, Graciosa Teixeira, Anita Ignatius, Jana Riegger

P152

Renal thrombotic microangiopathy with concurrent monoclonal gammopathy in China: A single center stud

Meng Tan, Ying Tan, Changhao Jia, Xiaojuan Yu, Daoxu Wu, Minghui Zhao

P153

The functions of IgG autoantibodies towards the C3bBb convertase drive the phenotype of C3 glomerulopathy

Julia Roquigny, Marie-Sophie Meuleman, Carine El Sissy, Mathilde Cailliez, Aude Servais, Gwenaelle Roussey, Véronique Baudouin, Stéphane Decramer, François Nobili, Alain Wynckel, Anne-Laure Sellier Leclerc, Anne-Laure Lapeyraque, Paula Vieira Martins, Seppo Meri, Marie-Agnès Dragon-Durey, Sophie Chauvet, Véronique Frémeaux-Bacchi

P154

Altered expression of FHR-1 and FHR-2 glycoforms in IgA nephropathy patients

Rosario García-Sánchez, Laura González-Sánchez, Irene Gómez-Delgado, Fernando Corvillo, Lina León, Gema Fernández-Juárez, Pilar Sánchez-Corral

P155

The immune modulatory effects of radiotherapy on the complement system

Magnus Trottnow, Selina Onoh, Teresa Irianto, Ann-Sophie Flohr, Azzaya Sengedorj, Lisa Deloch, Rainer Fietkau, Udo Gaipl, Michael Rückert

P156

Distinct sites of complement activation and regulation in the tumor microenvironment of colorectal cancer

Joanne van Keulen, Julie Alles, Esther de Boer, Gerard van Mierlo, Angela Kamp, Mark Hoogenboezem, Liudmila Kodach, Jan Paul de Boer, Taco Kuijpers, Richard Pouw

P157

"Unveiling Potential Synergy: Radiotherapy and Complement Inhibition in Cancer Therapy"

Gaia Volpi, Cristina Totis, Usama Dabbas, Niccolo Edgar Saccone, Elena Magrini, Cecilia Garlanda, Marco Giuseppe Pullia, Angelica Facoetti, Marco Durante, Alexander Helm, Claudia Fournier

P158

Renal biopsy proven TMA in elderly: an insight into clinical, laboratory features and outcomes

Harshita Sharma, Anupma Kaul, Manas Ranjan Behera, Dharmendra Singh Bahaduria, Narayan Prasad

P159

Aberrant complement activation is associated with structural brain damage in multiple sclerosis

Johanna Oechtering, Sabine Schaedelin, Kerstin Stein, Aleksandra Maceski, Lester Melie-Garcia, Pascal Benkert, Alessandro Cagol, Selina Leber, Riccardo Galbusera, Esther Ruberte, Wayne Hu, Ferhan Qureshi, Annette Orleth, Lilian Demuth, Eline Willemse, Ingmar Heijnen, Axel Regeniter, Tobias Derfuss, Bettina Fischer-Barnicol, Lutz Achtnichts, Stephanie Mueller, Robert Höpner, Patrice Lalive, Claire Bridel, Marcus DSouza, Caroline Pot, Renaud DuPasquier, Claudio Gobbi, Chiara Zecca, Heinz Wiendl, Johanna Lieb, Christina Lamers, Ludwig Kappos, Marten Trendelenburg, David Leppert, Cristina Granziera, Jan Luenemann, Jens Kuhle

P160

AUTOANTIBODIES AGAINST COMPLEMENT PROTEINS MEDIATE DISTINCT EFFECTS IN MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS PATIENTS

Alexandra Tünde Matola, Dániel Bencze, Zoltán Hérincs, Krisztián Papp, József Prechl, Dorottya Csuka, Zoltán Prohászka, Mihály Józsi, Barbara Uzonyi

P161

The pathogenic role of anti-C1qA08 antibodies in lupus nephritis

Ying Tan, Changhao Jia

P162

Metabolic control of complement factor D and the alternative pathway tickover in diabetes

Lucie Colineau, Olga Kolodziej, Daniel Ajona, Ruben Pio, Anna Blom, Ben King

P163

Evaluation of the proangiogenic role of the complement component C1q in endometriosis

Chiara Agostinis, Gabriella Zito, Miriam Toffoli, Andrea Balduit, Silvia Pegoraro, Giuseppe Ricci, Roberta Bulla

P164

Clinical and laboratory associations of elevated factor H levels in immune-mediated thrombotic thrombocytopenic purpura

Andreea-Adela Icleanu, Marienn Reti, Zoltán Prohászka, György Sinkovits

P165

Radiation-mediated complement alternative pathway activation within the lung tumor microenvironment diminishes the efficacy of therapy

Harendra Shah, Minakshi Saikia, Xiaobo Wu, John Atkinson, Dennis Hallahan, Abhay Singh, Vaishali Kapoor

P166

Complement activation in an underreported mouse model of pulmonary fibrosis

Peter Szachowicz, Christine Wohlford-Lenane, Alejandro Pezzulo, Nabeel Hamzeh, Paul McCray, Richard Smith

P167

The role of the complement system in pustular dermatoses

Katja Hertwig, Esther Tiessen, Johannes M. Weiss, Markus Huber-Lang, Marco Mannes

P168

Disruption of C5/C5a/C5aR1 Axis Promotes Obesity Accompanied by Hypothalamic Leptin Resistance and Subsequent Increased Food Intake

Elias Rawish, Carolin Gragoll, Jörg Köhl, Ingo Eitel

P169

Opposing effects of C3a and C5a on human osteoarthritic chondrocytes and synoviocytes

Hannah Köck, Kathrin Gottwald, Marianne Ehrnsperger, Susanne Grässel, Nicole Schäfer

P34

Potent inhibition of immune uptake and infusion toxicity of nanoparticles via surface-targeted complement regulators

Dmitri Dmitri Simberg

P81

Direct binding of complement components to immunodominant skin antigens: a key step in early autoimmune skin disease

Christoph Hammers

P127

GENETIC ANALYSIS IN DIARRHEA-ASSOCIATED STEC NEGATIVE HEMOLYTIC-UREMIC SYNDROME

Manuela Colucci, Debora Vezzoli, Federica Zotta, Alessandra Gianviti, Antonio Gargiulo, Francesco Emma, Marina Vivarelli

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